Spain and Italy have moved to restrict the usage of the Oxford/AstraZeneca vaccine to individuals aged above 60, in shifts that may complicate the international locations’ efforts to step up their vaccination programmes.
The selections by Madrid and Rome on Wednesday evening got here after the European Medicines Company mentioned earlier within the day that there was a hyperlink between very uncommon blood clots within the mind and the AstraZeneca jab.
Whereas the EMA, the EU’s prescription drugs regulator, didn’t change its steerage for who ought to take the vaccine, it famous that “to this point, many of the instances reported [of blood clots] have occurred in ladies below 60 years of age inside two weeks of vaccination”.
Belgium individually restricted the AstraZeneca vaccine to these aged 56 or older for no less than 4 weeks on Wednesday. Australia moved on Thursday to restrict additional use of the shot in these youthful than 50, with Canberra saying the BioNTech/Pfizer inoculation ought to be used as an alternative.
France and Germany had additionally beforehand restricted the usage of the shot for the over-55s and over-60s, respectively — trusting that different vaccines, reminiscent of that from BioNTech/Pfizer and a brand new one-shot inoculation from Johnson & Johnson, shall be adequate to make up the lag within the EU’s vaccination programme.
The UK, which is properly forward of the EU within the vaccine rollout, abruptly changed its guidance over the AstraZeneca vaccine on Wednesday, recommending that folks aged between 18 and 29 are supplied various jabs. Sweden and Finland permit its use solely within the over-65s, whereas Denmark and Norway have suspended its use till not less than subsequent week.
Spain’s choice to make use of the AstraZeneca vaccine just for individuals over 60 reverses the nation’s coverage of just some weeks in the past — till final month it banned the usage of the jab for these over 55.
The brand new stance might make it extra sophisticated to succeed in Spain’s objective — introduced on Tuesday by Prime Minister Pedro Sánchez — of vaccinating 70 per cent of the inhabitants, 33m individuals, by the tip of August.
Isabel Díaz Ayuso, head of the Madrid regional authorities, who’s searching for to retain her publish in elections subsequent month, criticised the rule change.
“You’ll be able to’t always change the factors,” she mentioned on Thursday. “You’ll be able to’t swap midway by means of the sport when many individuals are already vaccinated, and when there was finally starting to be some readability about which vaccines had been for which teams of individuals.”
Diversified recommendation on the Oxford/AstraZeneca vaccine
UK: Below-30s ought to be supplied a substitute for the AstraZeneca jab
Spain and Italy: Restrict to make use of in these over 60
Belgium: Use suspended in individuals below 56 for the subsequent 4 weeks
France and Canada: Restricted to make use of in over-55s
Germany: Beneficial just for these over 60
Sweden and Finland: Used just for over-65s
Denmark and Norway: Use suspended in all age teams till not less than subsequent week
Australia: Keep away from additional use on under-50s
At current, 6.4m Spaniards have acquired not less than one dose of a Covid-19 vaccine. Of these, barely greater than 2m have acquired the AstraZeneca jab, whose use had been accelerating in latest weeks. However, in response to official figures issued on Wednesday evening, solely 97 individuals in your entire nation have acquired a second AstraZeneca dose.
Carolina Darias, Spain’s well being minister, mentioned the nation had not determined whether or not to manage AstraZeneca or one other vaccine to individuals below 60 who had already acquired a primary shot of the jab.
The Italian well being ministry additionally issued new steerage in a single day saying the AstraZeneca vaccine ought to be given “preferential use” in these aged 60 and above. The steerage famous the chance of clots, whereas acknowledging that it was low, and including that the chance of extreme Covid-19 will increase with age.
Italian officers advised a press convention on Wednesday evening that the risk-benefit ratio was nonetheless considerably slanted in the direction of administering the vaccine. Italy had additionally initially restricted the usage of the vaccine to youthful sufferers, eradicating age limits as extra knowledge grew to become out there.
Rome’s new pointers clarified that those that had already acquired a dose of the AstraZeneca shot ought to full their vaccination with the identical jab, no matter age.
AstraZeneca on Wednesday acknowledged the findings from the EMA and the UK’s Medicines and Healthcare merchandise Regulatory Company, whereas noting that greater than 200m doses of the shot had been administered worldwide with a comparatively low variety of side-effects.
The Anglo-Swedish drugmaker mentioned it was working with international authorities to raised perceive the side-effects. The EMA has ordered additional research, to be carried out with the Utrecht College and the Erasmus college in Rotterdam.